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However, it also is possible that these patients use nicotine as a form of self-medication and to ameliorate certain symptoms associated with the disease (Goff et al, 1992; Mihailescu & Drucker-Col n, 2000) For example, patients with schizophrenia have abnormalities in sensory-gating, which can be improved following nicotine administration (Adler, Hoffer, Wiser, & Freedman, 1993) It has been hypothesized that nicotine can improve some of the negative symptoms of schizophrenia by increasing dopaminergic activity in the mesocorticolimbic pathway (Glassman, 1993) Thus, the ability of nicotine to enhance dopamine release could provide a possible explanation for the high frequency of smoking seen in patients with schizophrenia In a similar vein, there is a higher incidence of smoking in people who suffer from depression (Balfour & Ridley, 2000; Breslau, Kilbey, & Andreski, 1993; Choi et al, 1997; Covey, Glassman, & Stetner, 1998; Kelder et al, 2001).

THE USE OF COMPUTERS AT ALL STAGES OF THE RESEARCH PROCESS In the mid-twentieth century, computers were used in psychological research primarily for data analysis The few investigators of animal learning who used them transferred their written records into a machine-readable form, such as IBM cards with 10 rows and 80 columns of locations that could be punched out Other cards would be punched out with the program, perhaps written in FORTRAN Stacks of such cards would be brought to a central computer center for batch processing The next day the investigator would be given a report of the results that often indicated that a syntax error had been made This was superseded by time-shared computers that permitted entries of data and programs from remote entries from a Teletype machine, including paper tape that could transmit data at a rate of about 10 bits per second.

Friedberg, F, Dechene, L, McKenzie, M, & Fontanetta, R (2000) Symptom patterns in long-term chronic fatigue syndrome Journal of Psychosomatic Research, 48, 59 68 Friedberg, F, & Jason, L A (1998) Understanding chronic fatigue syndrome: An empirical guide to assessment and treatment Washington, DC: American Psychological Association Friedberg, F, & Krupp, L B (1994) A comparison of cognitive behavioral treatment for chronic fatigue syndrome and primary depression Clinical Infectious Diseases, 18, S105 S10 1 Fukuda, K, Straus, S E, Hickie, I, Sharpe, M C, Dobbins, J G, & Komaroff, A (1994) The chronic fatigue syndrome: A comprehensive approach to its de nition and study Annals of Internal Medicine, 121, 953 959 Fulcher, K Y, & White, P D (1997) Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome British Medical Journal, 314, 1647 1652.

The time-shared computers were convenient to access and presented faster reports of errors that could be immediately corrected, but they were still used almost exclusively for data analysis A major change in the use of computers in psychological research began in the mid-1960s, when a few investigators began to use laboratory computers for multiple purposes By current standards, these computers were large, slow, unreliable, expensive, and limited For example, the classic Link computer had only 1,000 12-bit words of memory, and a magnetic tape was its only permanent storage medium The revolutionary feature of these computers was that they could be used for control of experiments and recording of results, as well as for the analysis of data The modern personal computer is smaller, faster, more reliable, and less expensive than previous ones.

Gellhorn, E (1968) CNS tuning and its implications for neuropsychiatry Journal of Nervous and Mental Diseases, 147, 148 162 Gellhorn, E (1970) The emotions and the ergotropic and trophotropic systems Psychologische Forschung, 34, 48 94 Gilbert, D T, Fiske, S T, & Lindzey, G (1998) Social stigma In Handbook of social psychology (Vol 2) New York: Oxford University Press Girdano, D A, Everly, G S, Jr, & Dusek, D E (1990) Controlling stress and tension: A holistic approach Englewood Cliffs, NJ: Prentice-Hall Glaser, R, & Kiecolt-Glaser, J K (1998) Stress-associated immune modulation: Relevance to viral infections and chronic fatigue syndrome American Journal of Medicine, 105, 35 42 Goldstein, J A (1990) Chronic fatigue syndrome: The struggle for health Beverly Hills, CA: Chronic Fatigue Syndrome Institute Gow, J W, Simpson, K, Behan, P O, Chaudhuri, A, McKay, I C.

High levels of depression are associated with higher dependency on smoking (Breslau et al, 1993) Similar to ADHD and schizophrenia, it is possible that depressed individuals are selfmedicating to alleviate the symptoms of depression and this behavior could be an important factor for tobacco dependence However, another explanation could be that there might be a common genetic basis for the association of the two disease states (Breslau et al, 1993; Kendler et al, 1993)..